Designing, physiochemical confirmation, evaluation of biological and in-silico potential of Triorganotin(IV) complexes

• Synthesis of organotin(IV) carboxylates. Structural and spectroscopic characterization. In vitro anticancer antimicrobial activities. Interaction with SS-DNA via intercalative mode interaction. silico study. FTIR, NMR, CHN single crystal X-ray crystallography were used to validate a series three new triorganotin(IV) carboxylate complexes, R 3 Sn(L) for = Methyl ( 1 ), n -Butyl 2 ) Phenyl obtained from LH 4-[(2,5- dimethoxyphenyl carbamoyl ]butanoic acid. The coupling constant ? C-Sn-C values in solution-state NMR data suggest 5-coordinated environment around the Sn centre. , is bidentate bridging leading zigzag chain centre having distorted trigonal-bipyramidal geometry. compounds evaluated their interaction salmon sperm DNA found that they interact through an resulting hypochromism bathochromic shift as confirmed by UV–visible viscometric techniques. findings anti-microbial activity performed on five bacterial two fungus strains demonstrate some exhibit >80% inhibition certain bacteria >100% fungal strains. also cell viability tested human embryonic kidney (HEC-239) red blood cells (RBC). anti-cancer potential was assessed using cis -platin standard against malignant glioma U87 (MG-U87) lines, shown be most potent (IC 50 : 148.979 µM) at µM dose. DPPH anti-oxidant results revealed 91% maximum scavenging . follow principles drug-likeness have good bioavailability potential, according analysis conducted SwissADME webserver. Synopsis graphical abstract: They show significant lines. (HEC239)